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Advantage Multi for is a once a month topical application that contains a combination of the insecticide (imidacloprid) and the parasiticide (moxidectin). Advantage Multi for Dogs is used for the prevention of heartworm and the treatment and control of flea infestations, hookworms, roundworms and whipworms. Advantage Multi requires a prescription from your veterinarian.
For use in puppies (ages 7 weeks and up; 3 pounds and up) and dogs.
The active ingredient moxidectin is used for the prevention and control of heartworms and intestinal worms by disrupting nerve transmission resulting in the paralysis and death of the parasite. The active ingredient imidacloprid, acts on the nervous system of the flea to cause paralysis and subsequent death.
Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become severe, consult a veterinarian immediately. Safety has not been established in breeding, pregnant, or lactating dogs.
Advantage Multi (Bayer)
Imidacloprid, Moxidectin
10% imidacloprid
2.5% moxidectin
A prescription is required. Sold in 6 or 12 month color coded boxes according to your dog's weight.
The following side effects are possible with topical treatment in dogs:
Hair discoloration at application site, Local discomfort, Hot spots, Alopecia, Erythema (skin redness), Pruritus (itching), Swollen ears and face, Rash, Hives, Acute pulmonary edema, Labored breathing, Panting, Seizures, Muscle tremors, Ataxia (impaired coordination), Disorientation, Agitation, Restlessness, Weakness, Lethargy, Poor appetite, Salivation, Diarrhea or bloody diarrhea, and Vomiting
The following side effects are possible with accidental oral ingestion in dogs:
Poor appetite, Agitation, Disorientation, Lethargy, Ataxia (impaired coordination), Mydriasis (dilated pupils), Seizures, Muscle tremors, Vomiting, and Salivation.
The following side effects are possible with topical treatment in cats:
Neurologic signs, Agitation, Lethargy, Vomiting, Skin or application site reactions.
Apply the missed dose as soon as you remember. If it is almost time to apply the next dose, skip the missed dose and apply the next dose as directed. Do not apply 2 doses at once.
Seek emergency veterinary medical treatment. Symptoms of overdose may include depression, increased salivation, tremors, or incoordination.
Avoid excessive cold or heat. Store at temperatures between 4°C (39°F) and 25°C (77°F).
For the first 30 minutes after application ensure that dogs and cats cannot lick the product from the application sites. Separate treated pets from one another and from other pets to reduce the risk of accidental ingestion. Wash hands with soap and water after handling. Do not let children touch the treated pet's skin for at least 30 minutes after applying the product. Do not get these products in the pet's mouth or eyes.
| Dogs/Puppies: (7 weeks of age or older) | |
| Weight | Dosage |
| 3-9 lbs | While your dog is standing, apply Advantage Multi-9 for Dogs topically by parting the hair on the back of the dog between the shoulder blades until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. Apply each dose once, every 30 days |
| 9.1-20 lbs | While your dog is standing, apply Advantage Multi-20 for Dogs topically by parting the hair on the back of the dog between the shoulder blades until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. Apply each dose once, every 30 days |
| 20.1-55 lbs | While your dog is standing, apply Advantage Multi-55 for Dogs topically by parting the hair on the back of the dog between the shoulder blades until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Apply each dose once, every 30 days |
| 55.1-88 lbs | While your dog is standing, apply Advantage Multi-88 for Dogs topically by parting the hair on the back of the dog between the shoulder blades until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Apply each dose once, every 30 days |
| 88.1-110 lbs* | While your dog is standing, apply Advantage Multi-110 for Dogs topically by parting the hair on the back of the dog between the shoulder blades until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Apply each dose once, every 30 days |
| Horses: Do not use!: |
Should be stored at room temperature between 39° F and 86° F, avoiding excess heat or cold.
*For dogs over 110 lbs use the appropriate combination..
| Advantage Multi 9 for Dogs 3-9 lbs: | |
| Active Ingredients | Amount |
| Imidacloprid | 40 mg |
| Moxidectin | 10 mg |
| Advantage Multi 20 for Dogs 9.1-20 lbs: | |
| Active Ingredients | Amount |
| Imidacloprid | 100 mg |
| Moxidectin | 25 mg |
| Advantage Multi 55 for Dogs 20.1-55 lbs: | |
| Active Ingredients | Amount |
| Imidacloprid | 250 mg |
| Moxidectin | 62.5 mg |
| Advantage Multi 88 for Dogs 55.1-88 lbs: | |
| Active Ingredients | Amount |
| Imidacloprid | 400 mg |
| Moxidectin | 100 mg |
| Advantage Multi 110 for Dogs 88.1-110 lbs: | |
| Active Ingredients | Amount |
| Imidacloprid | 500 mg |
| Moxidectin | 125 mg |
Advantage Multi for dogs is a Once-a-month topical solution for the prevention of heartworm disease, kills adult fleas, is indicated for the treatment of flea infestations, as well as the treatment and control of intestinal parasite infections.
Revolution is a safe and simple monthly topical medication used to protect your pet from heartworms, fleas, and ear mites. It also protects dogs from ticks and sarcoptic mange and cats from roundworms and hookworms. Revolution for Dogs and Cats requires a prescription from your veterinarian.
Simplify your dog's heartworm and flea protection with Sentinel Spectrum, the only beef-flavored chewable to protect against 6 parasites. It is given monthly. Each chew also treats and controls whipworms, hookworms, roundworms and tapeworms. Sentinel Spectrum requires a prescription from your veterinarian
Revolution Plus for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. It kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestation.
Simparica Trio Chewable Tablets for Dogs prevents heartworms. Treats aand controls ticks (lone star ticks, black legged ticks, gulf coast ticks, american dog ticks, brown dog ticks). Treats and prevents flea infestations. Treats and controls roundworms, and adult hookworm infections.
Advantage Multi for Cats is a once-monthly topical product that controls and treats intestinal parasites like roundworm and hookworm, controls and treats ear mites, treats existing flea infestations, kills adult fleas, and prevents heartworm disease.
Bravecto Plus (Fluralaner/Moxidectin) is a Topical Spot On Solution for cats indicated for the treatment and prevention of flea and tick infestations, as well as preventing against heartworms, and the treatment of roundworms and hookworms for up to 8 weeks.
NexGard Plus (afoxolaner, moxidectin, and pyrantel chewable tablets) is the one you want for complete monthly parasite protection for your dog. It protects your dog from fleas and ticks, PLUS heartworm disease, roundworms, and hookworms – all in a delicious, beef-flavored, soft chew. NexGard Plus chews are safe and approved for puppies as young as 8 weeks old.
Credelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) is the widest parasite protection of its kind covering 6 types of parasites in one chewable tablet. It protects against ticks, fleas, heartworm disease and the three intestinal worms that can be passed to humans — tapeworms, roundworms and hookworms

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