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What is Trifexis?
Trifexis® (spinosad + milbemycin oxime) is the monthly, beef-flavored chewable tablet that kills fleas and prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm and whipworm infections. Trifexis is approved for use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. Trifexis requires a prescription from your veterinarian.
For:
Dogs (8 weeks of age and older and weighing at least 5 lbs)
Benefits:
- Begins killing fleas after 30 minutes of administration
- Kills fleas before they can lay eggs
- Prevents heartworm disease
- Treats and controls roundworms, hookworms, and whipworms
- Easy to administer
- Beef flavored chewable tablet
Cautions:
Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets.
Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.
Puppies less than 14 weeks of age may experience a higher rate of vomiting. Like all medications, keep Trifexis out of reach of children.
Brand Name
Trifexis (Elanco Animal Health)
Generic Name
Spinosad and Milbemycin oxime
What happens if I miss giving a dose:
Give the missed dose with food as soon as you remember and resume a monthly dosing schedule. If vomiting occurs within an hour of administration, redose with another full dose.
Possible side effects of Trifexis:
The most common adverse reactions reported are vomiting, depression/lethargy, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration.
Storage:
Should be stored at room temperature.
Directions:
Give Trifexis chewable tablets once a month with food. If vomiting occurs within 1 hour of administration, redose the pet with another full dose.
Dosage:
| Pet | Weight | Dosage |
|---|---|---|
Dogs (over 8 weeks of age) | 5 - 10 lbs | Give one tablet (Pink label box) |
| 10.1 - 20 lbs | Give one tablet (Orange label box) | |
| 20.1 - 40 lbs | Give one tablet (Green label box) | |
| 40.1 - 60 lbs | Give one tablet (Blue label box) | |
| 60.1 - 120 lbs | Give one tablet (Brown label box) | |
| Over 120 lbs | Administer the appropriate combination of tablets | |
| Cats: | X | X |
| Horses: | X | X |
Trifexis for Dogs 5 to 10 lbs:
| Active Ingredients per tablet | Amount |
|---|---|
| Spinosad | 140 mg |
| Milbemycin oxime | 2.3 mg |
Trifexis for Dogs 10.1 to 20 lbs:
| Active Ingredients per tablet | Amount |
|---|---|
| Spinosad | 270 mg |
| Milbemycin oxime | 4.5 mg |
Trifexis for Dogs 10.1 to 20 lbs:
| Active Ingredients per tablet | Amount |
|---|---|
| Spinosad | 560 mg |
| Milbemycin oxime | 9.3 mg |
Trifexis for Dogs 40.1 to 60 lbs:
| Active Ingredients per tablet | Amount |
|---|---|
| Spinosad | 810 mg |
| Milbemycin oxime | 13.5 mg |
Trifexis for Dogs 60.1 to 120 lbs:
| Active Ingredients per tablet | Amount |
|---|---|
| Spinosad | 1620 mg |
| Milbemycin oxime | 27 mg |
- Begins killing fleas after 30 minutes of administration
- Kills fleas before they can lay eggs
- Prevents heartworm disease
- Treats and controls roundworms, hookworms, and whipworms
- Easy to administer
- Beef flavored chewable tablet
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